Are you tired of hitting a wall during your workouts, dreading the post-exercise muscle soreness, and searching for that extra edge to boost your energy levels? Well, the latest findings from a groundbreaking study published in the Journal of Exercise and Nutrition might just have the answer you’ve been looking for.
This research, conducted by Greenberg et al. in 2023, unveils the exciting potential of Inositol-stabilized Arginine Silicate (ASI) or Nitrosigine®, in reducing exercise-induced muscle damage and supercharging your perceived energy levels.†
Nitrosigine is not your run-of-the-mill supplement. It’s a powerhouse compound that cranks up your circulating arginine and nitric oxide (NO) levels. Nitric oxide, often called the “miracle molecule,” is a game-changer in fitness. It widens your blood vessels, delivering a surge of nutrients to your muscles during workouts. So, let’s dive into the details of this study and see how Nitrosigine could revolutionize your fitness journey.†
There were sixteen volunteers participating in the study. This study was a “double-blind, placebo-controlled crossover study.” This means that neither the participants nor the researchers knew who received the supplement or a placebo. This setup helps eliminate biases that might affect the study’s results.†
Each day, the participants took a dose of ASI equivalent to 1,500 milligrams (mg). This dosage was given for four days, followed by a seven-day break without any supplementation. This break is called a “washout period” and is used to ensure that the effects of ASI from the first phase of the study don’t influence the results of the second phase.†
The researchers took measurements at various points in time: at the beginning of the study (baseline) and then at 24, 48, and 72 hours after the participants completed a leg extension exercise session. These time intervals allow them to track changes over the course of recovery.†
What Did They Measure?
To assess muscle recovery, the researchers looked at specific markers in the participants’ blood:
- Creatine Kinase (CK): This is an enzyme that’s released when muscles are damaged. Elevated CK levels can indicate muscle damage.†
- Myoglobin: Another marker of muscle damage, myoglobin is a protein found in muscle tissue. Increased levels suggest muscle stress.†
- Lactate Dehydrogenase (LDH): Like CK, LDH is an enzyme related to muscle damage.†
The study also used Doppler ultrasound and leg circumference measurements to examine blood flow to the exercised muscles. These measurements help gauge how well nutrients and oxygen are delivered to the muscles. The researchers also did checks of salivary nitrite levels to assess the body’s nitric oxide (NO) production. Nitric oxide is a molecule that relaxes blood vessels, improving blood flow to muscles during exercise.†
In addition to objective measurements, the study considered the participants’ subjective experiences:
- Profile of Mood States (POMS): This is a questionnaire used to assess mood and emotional state. It helps gauge how participants felt during the study.†
- Visual Analog Scales (VAS): These are rating scales used to collect participants’ subjective responses. This study likely used VAS scales to assess things like pain, fatigue, and overall well-being.†
- Vigor-Activity Cognitive Tests: These tests measure cognitive functions related to physical energy and alertness.†
Now, let’s take a closer look at the results of the study, which reveal the impressive effects of Inositol-stabilized Arginine Silicate (ASI), or Nitrosigine®, on muscle recovery, blood flow, and energy perception.
Reduction in Muscle Damage:
The ASI group shows a significant reduction in serum creatine kinase (CK) levels, a key marker of muscle damage, on day one post-exercise, and this trend continues at 24, 48, and 72 hours. This finding suggests that ASI actively helps protect muscles from damage during strenuous workouts.†
Moreover, myoglobin, another muscle damage indicator, decreases on day one and remains like this at the 24-hour mark. While ASI actively contributes to minimizing muscle damage, there are no notable effects on lactate dehydrogenase (LDH), indicating selective muscle protection by ASI.†
Enhanced Blood Flow:
Doppler ultrasound measurements vividly illustrate increased blood flow to exercised muscles in the ASI group. At the 72-hour mark, leg circumference, another measure of blood flow, indicates a significant increase. This active enhancement in blood flow ensures improved nutrient delivery to the muscles during and after exercise.†
Perceived Energy Boost:
While salivary nitrite levels did not actively show differences, participants in the ASI group did state an increase in perceived energy levels. These findings from their responses to the Profile of Mood States (POMS) questionnaire highlight ASI’s active role in enhancing overall energy and well-being during and after exercise.†
The findings of this study suggest that Nitrosigine or Inositol-stabilized Arginine Silicate (ASI) could be a valuable addition to your fitness regimen. By enhancing blood flow, reducing muscle damage, and increasing perceived energy levels, ASI may help you achieve your fitness goals more efficiently and with a quicker recovery time. It’s an exciting option for those looking to elevate their fitness journey but keep in mind that individual results will vary.†
Now that we’ve explored the exciting potential of Nitrosigine® let’s dive into the products that contain this innovative compound. In this section, we’ll explore some of the products that feature Nitrosigine®.
Please note this is not a comprehensive list of all products featuring this ingredient.
- Alpha Lion Gains Candy Nitrosigine
- Bucked Up Mother Bucker Pre Workout
- Black Magic Ecto Plasm
When it comes to optimizing your workout routine, finding the right supplement can make all the difference. Alpha Lion Gains Candy Nitrosigine is one such product that caught our attention, and here’s why.
Alpha Lion Gains Candy Nitrosigine boasts a substantial 1500 mg of Nitrosigine. This compound, as we saw from research, has the potential to enhance muscle recovery, improve blood flow, and boost energy perception during exercise. With its convenient capsule form, Gains Candy Nitrosigine can be easily added to your current pre workout stack or be taken all on its own. With 21 servings per bottle, you’ll have enough to fuel your workouts for weeks.†
How To Take Alpha Lion Gains Candy Nitrosigine:
The manufacturer suggests taking three (3) capsules 20-30 minutes prior to your training session.
Bucked Up Mother Bucker Pre Workout doesn’t hold back when it comes to delivering a potent combination of performance-enhancing compounds. Let’s break down what this product has to offer.
Powerful Ingredients Lineup:
One glance at the list of ingredients in Mother Bucker Pre Workout, and it’s clear that this formula is designed to supercharge your workouts. Some notable components include:
- Beta Alanine (6.4g): Known for its endurance-boosting properties, it helps you power through those tough reps.†
- L-Citrulline (4g): Enhances blood flow, which can lead to better muscle pumps and improved nutrient delivery.†
- Nitrosigine (1.5g): We’ve seen the potential benefits of Nitrosigine in muscle recovery and energy perception.†
- Caffeine Anhydrous (300mg): Provides a clean energy kick to keep you focused and energized.†
If you’re seeking a pre-workout supplement that packs a punch, Bucked Up Mother Bucker Pre Workout is worth considering. Its comprehensive ingredient profile, clear dosing instructions, and potent formula make it a solid choice for those looking to elevate their workouts. However, it’s worth noting that Mother Bucker Pre Workout is potent, so the manufacturer recommends starting with no more than one scoop and testing your tolerance with half a scoop initially. With 20 servings per bottle, it offers a substantial supply to fuel your workouts.†
How To Take Mother Bucker:
The manufacturers suggest mixing one (1) rounded scoop into 8oz of water 15-30 minutes prior to physical activity.
Black Magic Ecto Plasm Pre Workout is a strong contender if you’re looking for a pre-workout supplement that combines tried-and-true ingredients with natural boosts. Let’s dive into what this product has to offer and why it might be your next fitness companion.
Potent Lineup of Ingredients:
Ecto Plasm doesn’t hold back when it comes to delivering a powerhouse of performance-enhancing ingredients. Here are some of the key components:
- Citrulline Malate (8g): Known for its role in enhancing blood flow and muscle pumps, this ingredient can help you feel the benefits of your workout more intensely.†
- Betaine Anhydrous (2.5g): Linked to improved power and strength output, making it an excellent addition for those looking to push their limits.†
- Glycerpump (2g): Enhances muscle cell hydration, potentially improving endurance and muscle fullness.†
- Nitrosigine (1.5g): We’ve already seen the potential benefits of Nitrosigine in muscle recovery and energy perception.†
Black Magic Ecto Plasm Pre Workout features a comprehensive ingredient profile, simple dosing instructions, and a unique blend of natural extracts, making it a noteworthy choice for those seeking to maximize their workouts.
How To Take Ecto Plasm:
The manufacturers suggest mixing one (1) scoop into 8-12oz of water 10-20 minutes prior to working out.
As we wrap things up, here’s a quick recap: We’ve explored some impressive fitness supplements containing Nitrosigine, a special ingredient. We’ve reviewed Alpha Lion Gains Candy Nitrosigine and Bucked Up Mother Bucker Pre Workout, and we’ve also talked about Black Magic Ecto Plasm Pre Workout.
These products have ingredients that can give you more energy for your workouts, help your muscles recover, and make your workouts more effective. Whether you’re a serious athlete or just someone who loves staying fit, these supplements might be exactly what you need to take your fitness routine to the next level.†
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Greenberg, D., Emerson, K., Ojalvo Perez, S., Sylla, S., & Komorowski, J. (2023). Inositol-Stabilized Arginine Silicate Reduces Exercise-Induced Muscle Damage and Increases Perceived Energy: Original Research. Journal of Exercise and Nutrition, 6(1). https://doi.org/10.53520/jen2023.103141 (Original work published March 1, 2023)
The products mentioned in this post are intended for healthy adults over the age of 18. Do not use these products if you are pregnant or nursing. Consult with a qualified healthcare professional before you take any medications or have any medical conditions.
†PLEASE NOTE: The intention of the information provided is for reference only. Furthermore, we are in no way providing medical advice or instruction. Instead, the information provided in this guide/blog utilizes anecdotal information and available studies/reviews. While our goal is to maintain and display accurate information, we can’t guarantee it represents the latest formulation of the product or information. Therefore, please visit the manufacturer’s website if you have any concerns. Also, the information above does not represent our views here at Same Day Supplements. Instead, these are the manufacturers’ and users’ views and information. The Food and Drug Administration has not evaluated these statements. Finally, these products aim not to diagnose, treat, cure, or prevent any disease or illness.